Best flea and tick and heartworm medicine for dogs

To treat for fleas and ticks, or just fleas?

The first thing to consider is which parasites are actually a risk in your area. While fleas are generally considered to be Australia-wide, paralysis ticks tend to have geographical hot spots.

Where are ticks found in Australia? Generally, paralysis ticks are mostly found along the East Coast of Australia. However, vet clinics as far west as Melbourne have reported paralysis tick cases in recent years.

Infographic of known geographic distribution of ticks in Australia. From Barker & Barker 2021 (in press). "Ticks of Australasia". Magnolia Press.

While the Brown Dog Tick and the Cattle Tick can spread diseases, such as Ehrlichiosis, only the Paralysis Tick causes deadly paralysis. Most tick prevention products cover all species of ticks.

Many people in temperate parts of the country get by without tick protection and tend to just use flea protection. However, while maps are helpful, we recommend checking with your local vet clinic as they will know whether ticks are a problem in your area.

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Topical or Oral?

Definitions:
"Topical" refers to 'spot on' treatments - or anything that is applied externally on your pet.
"Oral" refers to chewables or tablets, which are given internally via your pet's mouth.

Note: there is currently no oral treatment for cats that covers for ticks, only topical treatments or collars.

So which is better, topical or oral treatments? In general, most vets in high-risk tick areas believe that oral treatments are the most effective form of flea and tick prevention in dogs. This is partly due to the fact that at the moment, oral treatments tend to contain newer drugs, which seem to have less resistance. An exception to this is the recently released Bravecto spot-on which is available for cats and dogs.

Another reason why vets tend to prefer oral treatments is that there is less room for human error. With oral treatments, efficacy is generally guaranteed so long as your dog swallows the chew (or tablet) and doesn't vomit soon after. Topical treatments, on the other hand, require a little more skill with application, and won't work if your dog gets wet up to 48 hours afterwards, or if you apply to the wrong part of the fur. Because many topicals need to be absorbed through the skin in order to work, the pet owner needs to ensure the liquid is applied onto the skin - just splatting it onto the outer layer of fur won't work.

Do topical flea treatments get absorbed through the skin? This is a common question and unfortunately the answer differs depending on the product. While most topical treatments need to get absorbed through the skin in order to work (which is why you need to part the fur so well!), some products work by dispersing along the outside of the coat, in the fatty lipid layer of your pet's natural skin oils. For more detail about a particular product, we recommend checking with the manufacturer.

To summarise, here are the pro's and cons of each:

Benefits of TOPICAL prevention
- Easier to apply in dogs who can't be tableted or won't eat chewables
- Some brands do not enter the bloodstream

Cons of TOPICAL prevention:
- Most lose effectiveness if your pet gets wet within 48 hours of application
- Typically older drugs which may have reduced effectiveness in high risk flea and tick areas (apart from Bravecto, Bravecto Plus and Revolution Plus)
- Open to human error - the full tube must be applied in contact with the skin (not on top of the outer fur layer)
- Some treatments leave a chemical smell on your pet's fur

Benefits of ORAL prevention
- Doesn't matter if your dog gets wet after administration (won't wash off as it's oral)
- Most are modern drugs with less resistance, therefore more effective in high risk areas

Cons of ORAL prevention
- Some pets may vomit medication up
- Harder to give in pets who won't take chewables or tablets

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Frequency of Treatment

There are now flea and tick prevention products to suit a whole range of schedules. Some brands only need to be given every 3, 4 or 6 months. This is extremely convenient if you are also giving a 3-monthly wormer.

For dogs, Bravecto chewables are given every 3 months, Seresto controls ticks for 4 months and fleas for 8 months, and Bravecto Spot Ons protect against fleas and ticks for a full 6 months.

For cats, Bravecto Spot On provides protection for 3 months from fleas and paralysis ticks, while Seresto controls both fleas and ticks for 8 months.

However, there are still plenty of people who prefer to give a monthly treatment, as they might find it easier to remember, or perhaps they are already giving monthly heart worm tablets and it lines up well with this. Simparica is a good example of a monthly flea and tick treatment.

Fortnightly application is generally considered less convenient, but there may be reasons you wish to choose a fortnightly application.

See the table at the bottom of this article to find out how long each product lasts for.

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To combine with worming, or not to combine?...

Which is best - a flea and tick only product, or a combination product which takes care of worming too? The truth is, it all depends on your personal preference. Many of the different products use similar drugs, so you don't need to worry about a 'combination' product being less effective than a 'flea and tick only' product.

Giving a flea and tick treatment separate to worming can have its benefits - for example, some people might only wish to give flea treatment in the warmer times of the year, but need to continue worming all year round. But for other people, combining everything they need into one treatment is very convenient indeed.

All-in-One Treatments

Now, we should just make something clear - there is no true 'all-in-one' product in existence (yet!). The term 'all in one' gets thrown around by manufacturers a lot, but alas no - there is currently no single product that covers absolutely every significant Australian parasite.

There are, however a few products which come close:

- Nexgard Spectra (dogs only) was released in 2017 as the first product to cover for fleas, worms, intestinal worms (including flea tapeworm) and ticks. The only major parasite it doesn't cover is the hydatid tapeworm.
- Simparica Trio (dogs only) was released in 2020 and has similar coverage to Nexgard Spectra - protecting against fleas, ticks, most intestinal worms (not tapeworm or whipworm), and heartworm.
- Credelio Plus (dogs only) also protects against fleas, ticks, heartworm, and intestinal worms including flea tapeworm. It does not provide protection against hydatid tapeworm.
- Bravecto Plus (cats only) is an easy spot-on product which keeps kitty cats protected against fleas, ticks, mites, intestinal worms, and heartworm. Again, it lacks only tapeworm prevention. A major advantage for Bravecto Plus is that it only needs to be given once every two months.
- Revolution Plus (cats only) is an easy spot-on product similar to Bravecto Plus, except it requires monthly dosing. It protects cats against fleas, ticks, mites, intestinal worms (apart from, you guessed it, tapeworm!), and heartworm.

There are plenty of products on the market which cover for fleas, worms, and heart worm, but don't have tick coverage. These products include Comfortis Plus, Sentinel, Advocate, and Revolution. These products might be perfect for pets in areas that are unaffected by paralysis ticks, such as Perth or Adelaide.

Shop All Flea, Tick and Worm Combination Products

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How to Choose Which Parasite Prevention You Need

The easiest way to know which parasite prevention you need is actually quite simple - start by looking at your heartworm regime. (Note: the below advice applies for dogs only, as the heartworm injection is not available for cats.)

Ask yourself: Do I want to get a yearly heartworm injection at the vet?

If you do choose to get the yearly heartworm injection, you'll still need to give an intestinal wormer every 3 months. It might then be most convenient to give your flea and tick prevention every 3 months, too, so they line up together. The best flea and tick option for you, therefore, would be the 3 monthly Bravecto chew.

If you do not choose to get a heart worm injection, you'll need to give heartworm prevention every month. It might then be most convenient to give your flea and tick prevention every month too, so they line up together. Therefore, the best preventative for you might be a combination product like Nexgard Spectra, or you can use a separate flea and tick product like Simparica with a wormer that covers for heart worm and intestinal worms such as Interceptor.

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What do our vets recommend?

After an educated review of flea and tick products? We asked our in-house vets what they think, and what they personally prefer...

Dr Carla - I am from Queensland, where ticks are particularly prevalent. For dogs, I always recommend one of the newer oral chews such as Simparica Trio or Credelio Plus as they work so effectively against paralysis ticks. For cats, I recommend the new Bravecto Plus spot-on tubes.

Dr Kes - For dogs, I personally recommend Nexgard Spectra. It's a monthly chewable that covers the four major parasites - paralysis ticks, fleas, heartworm and intestinal worms. For cats, I recommend a combination topical treatment such as Revolution Plus.

Dr Teagan - For dogs I highly recommend using one of the new generation combined flea and tick treatments such as Bravecto, Nexgard or Simparica for reliable, year round protection from ticks and fleas. For cats, I use and recommend Revolution as it includes protection against heartworm and intestinal worms in addition to fleas. For cats in tick paralysis areas I find the safest tick preventative is to keep them indoors! If they must go outside then I recommend using Bravecto spot-on for tick prevention.

Dr Elise - In Melbourne I was very happy recommending Advocate monthly for flea, intestinal worm and heartworm prevention for my dog and my client's pets. However on relocating back to Queensland and living in a tick prone zone I have had to switch to a product that includes reliable tick preventation like the 3-monthly chewable Bravecto or monthly Nexgard Spectra. For indoor cats I still recommend Advocate however if they head outside when ticks are around I recommend adding in Frontline spray every 3 weeks.

Want some advice on which product is best for your pet? Visit our Vet Pet Plan page.

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Which flea product is the best value?

Here we have it - the million dollar question. Which is the cheapest flea treatment? As you may have realised, it's difficult to directly compare the cost and value of different flea and tick treatments, as they differ in how frequently they need to be given. So we've taken the hard work out for you and done a bit of a comparison table based on their value per month.

For the purpose of this comparison, we've provided the cost for three different sized dogs - 5kg (small breed), 20kg (medium breed), and 40kg (large breed). We've also focused on products that protect against both fleas and ticks, at their recommended dosage for both parasites.

Note - for a comparison of which parasites each product covers, see our table at the bottom of this article.

Product NameFrequencyPack SizeCost Per PackCost Per Month

Bravecto chew

Every 3 months* 1 chew

5kg dog: $47.99

20kg dog: $47.99

40kg dog: $47.99

5kg dog: $16

20kg dog: $16

40kg dog: $16

Bravecto spot-on

Every 6 months 1 topical tube

5kg dog: $81.77

20kg dog: $81.77

40kg dog: $81.77

5kg dog: $13.62

20kg dog: $13.62

40kg dog: $13.62

Nexgard

Every month 6 chews

5kg dog: $70.75

20kg dog: $75.43

40kg dog: $80.37

5kg dog: $11.79

20kg dog: $12.57

40kg dog: $13.40

Seresto

Every 4 months** 1 collar

5kg dog: $44.99

20kg dog: $44.99

40kg dog: $44.99

5kg dog: $11.25

20kg dog: $11.25

40kg dog: $11.25

Simparica

Every month 6 chews

5kg dog: $69.99

20kg dog: $73.59

40kg dog: $80.99

5kg dog: $11.67

20kg dog: $12.27

40kg dog: $13.50

Advantix

Every 2 weeks 6 pipettes

5kg dog: $67.21

20kg dog: $71.13

40kg dog: $72.79

5kg dog: $22.40

20kg dog: $23.71

40kg dog: $24.26

*For ticks alone, Bravecto chew only needs to be given every 4 months.

**For fleas alone, Seresto has 8 months coverage.

Note: The prices above were accurate at time of publication. Prices may fluctuate; please consult links above to see current prices of any specific products.

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Complete Comparison Table

See a complete breakdown of all available flea and tick products below. These tables provide an unbiased comparison of all products, what parasites they each cover, and for how long.

(Skip to Table for Cat Products)

DOG Products Comparison Table

Product Ticks Fleas Heartworm Intestinal Worms Tapeworm Type

Advantage 1 month Topical

Advantix 2 weeks 4 weeks Topical

Advocate 1 month 1 month 1 month Topical

Aristopet Fleas, Heartworm & Worms 1 month 1 month 1 month Topical

Aristopet All Wormer 3 months* 3 months* Tablet

Bravecto 4 months Chewable
6 months Topical
3 months Chewable
6 months Topical

  • Chewable
  • Topical

Capstar 24 hours Tablet

Comfortis 1 month Chewable

Comfortis Plus 1 month 1 month 1 month Chewable

Credelio 1 month 1 month Chewable Tablet

Credelio Plus 1 month 1 month 1 month 1 month Chewable Tablet

Drontal 3 months* 3 months*

  • Chewable
  • Tablet
  • Liquid

Evicto 1 month 1 month 1 month Topical

Frontline Plus 2 weeks 4 weeks Topical

Heartguard Plus 1 month 1 month Chewable

Interceptor 1 month 1 month 1 month Chewable

Kiltix 6 weeks 5 months Collar

Milbemax 1 month 3 months* 3 months* Tablet

Milpro 1 month 3 months* 3 months* Topical

Neovela 1 month 1 month 1 month Topical

Neoveon 2 weeks 4 weeks Topical

Neovet 1 month 1 month 1 month Topical

Nexgard 1 month 1 month Chewable

Nexgard Spectra 1 month 1 month 1 month 1 month Chewable

Paragard 3 months* 3 months* Tablet

Revolution 1 month 1 month 1 month Topical

Sentinel Spectrum 1 month 1 month 1 month 1 month Chewable

Seresto 4 months 8 months Collar

Simparica 1 month 1 month Chewable

Simparica Trio 1 month 1 month 1 month 1 month Chewable

Valuheart 1 month Tablet

* Please Note: The worming recommendation of 3 months is based on an adult dog. Puppies are required to be wormed more often. For a worming guide for puppies, see our veterinary written article New Puppy Guide.

CAT Products Comparison Table

What is the best flea tick and heartworm medication for dogs?

Best Overall Flea Medicine for Dogs Veterinarians recommend Simparica Trio because of its effective protection against ticks and fleas, as well as heartworms, roundworms, and hookworms—all in one convenient monthly chew. It's a small, liver-flavored chewable tablet available by prescription.

Is there a heartworm flea and tick all in one?

Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, five types of ticks, fleas, roundworms and hookworms, all in one monthly chewable. Is Simparica Trio safe?

What is the safest and most effective flea and tick treatment for dogs?

Bravecto Chew for Dogs Bravecto Chew is also effective in killing adult fleas, so it can help reduce the risk of your dog getting flea bite dermatitis. If you're looking for a safe and effective flea and tick treatment for your dog, Bravecto Chew is the way to go.

Which is safer NexGard or Simparica?

Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.

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