Clinical Trial Show
. 1993 Sep-Oct;64(5):533-7. [Article in Italian] Affiliations
Clinical Trial [Rationale for the use of bile salts after cholecystectomy: results of a controlled clinical study using tauroursodeoxycholic acid (TUDCA)][Article in Italian] E Croce et al. Ann Ital Chir. 1993 Sep-Oct. AbstractCholecystectomy causes alterations in bile composition. In particular it rises the proportion of highly detergent bile acids with the possible consequence of the manifestation of dyspepsia in a high percentage of patients: this is the well-known post-cholecystectomy syndrome. In this clinical trial we studied the activity and safety of tauroursodeoxycholic acid--TUDCA--(500 mg/die) in the prevention of dyspepsia in cholecystectomized patients, in comparison with no treated group. We enrolled 203 patients (101 TUDCA--group A--and 102 control-group B). The two groups were comparable for age (47.1 years in group A and 50.7 years in group B), sex (m/f: 28/73 and 37/65 in the two groups) and for other characteristics connected to surgical procedures. After operation all patients suffered from dyspepsia symptoms. In patients treated with TUDCA we registered a prompt regression in severity of symptoms when compared with no treated group: in fact we noted a significant difference only at the first control planned after one month from operation. No difference were registered at the other controls (two and three months after operation). Two patients in A and 3 in group B manifested adverse events. In conclusion, the treatment with TUDCA, a new hydrophilic bile acid, seems to contribute to the improvement of clinical course in cholecystectomized patients. Similar articles
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Q. I have read that people who have had their gallbladders removed should take bile salts. My gallbladder was removed many years ago, and no doctor has said I should take bile salts. Should I? A. Bile salts are produced in the liver, secreted into the bile ducts and gallbladder, and sent from there to the small intestine by way of the common bile duct. In the intestine, bile salts make it easier for your body to absorb and digest the fats and fat-soluble vitamins that you've eaten. Remember, not all fats are bad: there are "good" fats, and they are crucial to our health. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Can you take ox bile if you have no gallbladder?Take an ox bile supplement. This is the most important recommendation for people who have lost their gallbladder. A lack of bile can produce symptoms such as bloating and indigestion after meals, light colored stools, diarrhea, fatigue after meals and nutrient deficiencies.
Should you take a bile supplement after gallbladder removal?Supplementing with Bile Salts has been suggested for those with biliary sludge (build up of bile) but not for individuals who have had their gallbladder removed. Experts at Harvard Health claim that there is no reason to supplement bile salts as long as you have a healthy functioning liver.
What are the best digestive enzymes for no gallbladder?Pancreatic lipase enzymes can help compensate for the lack of bile that is common with gallbladder removal.
What vitamins should I take if I had my gallbladder removed?Not digesting fat well means you will not be able to digest essential fatty acids, including omega 3 and omega 6 fats. It also means you'll have a hard time absorbing fat soluble vitamins such as vitamins D, E, A and K. These nutrients are vital for good health, and you will probably need to take a supplement.
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