Women taking daily amounts of non-aspirin painkillers — such as an extra-strength Tylenol — are more likely to develop high blood pressure than those who don’t, a new study suggests. While many popular over-the-counter painkillers have been linked before to high blood pressure, acetaminophen, sold as Tylenol, has generally been considered relatively free of such risk. It is the only one that is not a non-steroidal anti-inflammatory drug or NSAID, a class of medications the federal government just required to carry stricter warning labels because of the risk for heart-related problems. Those include ibuprofen (sold as Advil and Motrin) and naproxen (sold as Aleve). Many had turned to those painkillers in the wake of problems with prescription drugs, such as Vioxx. However, the new study found that women taking Tylenol were about twice as likely to develop blood pressure problems. Risk also rose for women taking NSAIDS other than aspirin. “If you’re taking these over-the-counter medications at high dosages on a regular basis, make sure that you report it to your doctor and you’re checking your blood pressure,” said Dr. Christie Ballantyne, a cardiologist at the Methodist DeBakey Heart Center in Houston who had no role in the study. The research found that aspirin still remains the safest medicine for pain relief. It has long been known to reduce the risk of cardiovascular problems and was not included in the government’s requirement for stricter labels for NSAIDs. The study involved 5,123 women participating in the Nurses Health Study at Harvard Medical School and Brigham and Women’s Hospital in Boston. None had had high blood pressure when it began. Use doubles risk of hypertension  “It certainly sets the basis for more studies,” said Dr. Stephanie Lawhorn, a cardiologist at St. Luke’s Mid America Heart Institute in Kansas City. “Most of the time we think that things like acetaminophen are fairly safe drugs.” In this study, the risk of developing high blood pressure for women who weren’t taking painkillers was about 1 to 3 percent a year, researchers said. They found that that women ages 51-77 who took an average daily dose of more than 500 milligrams of acetaminophen — one extra-strength Tylenol — had about double the risk of developing high blood pressure within about three years. Women in that age range who take more than 400 mg a day of NSAIDS — equal to say two ibuprofen — had a 78 percent increased risk of developing high blood pressure over those who didn’t take the drug. Among women 34-53 who take an average of more than 500 mg of acetaminophen a day had a two-fold higher risk of developing high blood pressure. And those who took more than 400 mg of NSAIDS a day had a 60 percent risk increase over those who didn’t take the pills. “We are by no means suggesting that women with chronic pain conditions not receive treatment for their pain,” lead author Dr. John Phillip Forman, of Harvard Medical School and associate physician at Brigham and Women’s Hospital in Boston, said in an e-mail. “By pointing out risks associated with these drugs, more informed choices can be made by women and their clinicians.” Previous research linking these drugs to blood pressure problems did not look at dose. The results in this study held up even when researchers excluded women who were taking pills for headaches, something that could itself be a result of very high blood pressure, said Dr. Gary Curhan, another study author also of Harvard Medical School. As for why aspirin didn’t raise risk, it might be because “aspirin has a different effect on blood vessels than NSAIDS and acetaminophen have,” said Dr. Daniel Jones, dean of the school of medicine at University of Mississippi Medical Center in Jackson. New survey commissioned by the American Heart Association found high blood pressure patients unsure of how to safely treat pain DALLAS, Nov. 2, 2021 – While nearly half of U.S. adults have high blood pressure (HBP), only 29% think over-the-counter (OTC) pain relievers may raise blood pressure, according to a recent survey commissioned by the American Heart Association, the leading voluntary health organization devoted to a world of longer, healthier lives for all. According to the American Heart Association’s 2017 Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure, high blood pressure is defined as a consistent blood pressure measurement of 130 over 80 or higher. The guidelines also state that some OTC pain relievers may elevate blood pressure. While majority of adults in the general population, as well as people with high blood pressure, aren’t sure about the effect of OTC pain medicine on their blood pressure, only a little more than half of those diagnosed with high blood pressure, who take OTC pain relievers (53%) check with their doctor before taking this medicine. “People who have high blood pressure or are being treated with blood pressure medication – along with their loved ones and caretakers – need to be informed about safe over-the-counter pain relievers,” said Willie Lawrence, Jr., M.D., interventional cardiologist, medical director for health equity, Spectrum Health in Benton Harbor, Michigan, and volunteer lead of the American Heart Association’s National Hypertension Control Initiative oversight committee. “Because some pain relievers may cause elevated blood pressure, the American Heart Association recommends consulting your doctor or pharmacist and making sure you read the label before taking any over-the-counter medication for pain, especially if you’ve been diagnosed with high blood pressure.” Conducted by The Harris Poll, the survey polled 2,013 U.S. adults aged 18 and older. Additional findings from the survey include:
In the U.S., high blood pressure is the No. 1 preventable cause of heart disease and stroke and second only to cigarette smoking as a preventable cause of death for any reason. Checking your blood pressure regularly at home with a validated blood pressure device for the most accurate reading and working with your doctor on a plan to control it, is a proven way to manage your blood pressure. For more information on managing high blood pressure, visit https://www.heart.org/bptools. ### About the American Heart Association The American Heart Association is a relentless force for a world of longer, healthier lives. We are dedicated to ensuring equitable health in all communities. Through collaboration with numerous organizations, and powered by millions of volunteers, we fund innovative research, advocate for the public’s health and share lifesaving resources. The Dallas-based organization has been a leading source of health information for nearly a century. Connect with us on heart.org, Facebook, Twitter or by calling 1-800-AHA-USA1. About the Survey This survey was conducted online within the United States by The Harris Poll on behalf of the American Heart Association from June 24-28,2021 among 2,013 U.S. adults ages 18 and older. This online survey is not based on a probability sample and therefore no estimate of theoretical sampling error can be calculated. For complete survey methodology, including weighting variables and subgroup sample sizes, please contact Toiya Honoré, national director, communications, American Heart Association. For Media Inquiries: Toiya Honoré ; 214-706-1456 For Public Inquiries: 1-800-AHA-USA1 (242-8721) |
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