How long does it take for ibuprofen to work?: FAQ about NSAIDS
Ibuprofen is a common non-steroidal anti-inflammatory drug (NSAID) used to relieve pain from musculoskeletal disorders such as arthritis, ligament tear, and tendon inflammation. We answer frequently asked questions on ibuprofen, such as how long does it take ibuprofen to start working.
How it works
Ibuprofen inhibits prostaglandins, which are critical inflammatory proteins. It does this by inhibiting enzymes called cyclooxygenase type 1 and type 2. By reducing the levels of prostaglandins, inflammation is lowered. Generally, we regard ibuprofen as an anti-inflammatory and pain-reliever.
Other NSAIDs
Ibuprofen is only one of many NSAIDs available. Overall, the group can be divided into a non-selective and selective groups. The non-selective group blocks both cycloxygenase enzymes. Examples of non-selective NSAIDs include ibuprofen, diclofenac, and naproxen. Alternatively, the selective group only blocks cyclooxygenase type 2, meaning that this group has fewer gastric side effects. Examples of selective NSAIDs include Celexocib, Etoricoxib, and Etodolac.
What conditions respond to ibuprofen and NSAIDs?
Generally, any condition that causes inflammation will respond to NSAIDs. These conditions include tendon pain, ligament sprain, and joint inflammation. Commonly, doctors prescribe these drugs for arthritis, such as osteoarthritis and rheumatoid arthritis.
A recent study found that Diclofenac (Voltarol) and Etoricoxib are the most effective pain killer for knee and hip arthritis. But etoricoxib is less likely to cause stomach ulcers. In addition, diclofenac gel is the most effective topical treatment for knee arthritis. However, opioids such as codeine or tramadol are ineffective and have an increased risk of side effects. Finally, paracetamol is the least effective for arthritis.
How long does it take for ibuprofen to work?
In general, it takes more than one dose for ibuprofen to work. This is because the pain-relieving effect doesn’t start until you take the third or fourth dose.
Side effects of ibuprofen and other NSAIDs
While most people who take ibuprofen do not experience side effects, a few potential side effects deserve mention.
Gastric side effects
Generally, the most common side effect is stomach inflammation, such as gastritis or ulcers. While most stomach side effects are mild, the consequences may be severe or fatal occasionally. In general, side effects that may be serious include severe abdominal pain, blood in the stool or coughing up, or vomiting blood. In general, people at most risk of bleeding include the elderly, those with a history of bleeding, or those taking blood thinners or steroids. However, suppose you are in the higher risk category. In that case, simple measures to reduce your risk include using a COX-2 group of NSAIDS (such as Celebrex or Arcoxia) and taking an extra tablet that protects the gut lining, such as omeprazole.
Heart side effects
In addition, NSAIDs can increase your risk of heart problems such as raised blood pressure, heart attacks, and stroke. If you’ve had a heart attack before, it is advisable to use the lowest possible dose of an NSAID such as ibuprofen or Naproxen for the shortest time.
Allergy is another common side effect producing swelling, wheezing, and shortness of breath. Overall, this is a severe side effect, which requires you to stop NSAIDs immediately and call your doctor. Finally, you should avoid NSAIDs if you have the following conditions: liver or kidney disease, clotting disorders, or severe asthma.
How long can I take ibuprofen safely?
Generally, there are no hard and fast rules about how long you can take NSAIDs safely. The time on NSAIDs depends on the severity of the condition treated and the patient’s risks in taking them. Overall, doctors suggest a short-acting NSAID for the least amount of time at the lowest dose to produce an effect. Ibuprofen is a good option.
Can I drink alcohol with ibuprofen?
Overall, the answer depends on your general risk. If you have liver or kidney disease or a history of stomach ulcers, doctors suggest you refrain or significantly limit your alcohol while taking NSAIDs. If you are at low risk, alcohol consumed in moderation – no more than two drinks per day- is unlikely to be harmful.
Are NSAIDs allowed in pregnancy?
In general, you should avoid NSAIDs in pregnancy due to potential developmental defects and increased risk of bleeding. You should also avoid NSAID cream or gel. Overall, alternatives, such as cortisone injection (which is safe) or paracetamol/codeine, should be considered.
Does topical ibuprofen work?
Yes. So, in a recent study comparing NSAID tablets to gel for knee or hand arthritis, the topical gel performed as well as the tablets. Moreover, the gel had fewer side effects as the absorption was less than the tablets. In another study, diclofenac gel was the best topical gel for knee arthritis. In general, doctors suggest using NSAID gel first for arthritis of the hands or knees.
Other common questions about ibuprofen and NSAIDs
Do NSAIDs raise blood pressure?
Yes. But this effect is only a concern if you have high blood pressure already. Also, the impact on blood pressure only lasts while taking ibuprofen. Once you stop the medication, your blood pressure returns to its usual level.
Can you take ibuprofen with alcohol?
Yes. However, drinking alcohol can increase the chances of developing stomach side effects. So, we recommend you restrict your alcohol intake a little while taking any NSAID.
Can you take ibuprofen with prednisone?
Prednisone is a strong anti-inflammatory tablet with similar side effects, including stomach side effects. Therefore, we advise against taking these two tablets together as the risk of stomach side effects increases significantly.
Final word from Sportdoctorlondon about how long does it take for ibuprofen to start working
Overall, there is no doubt that NSAIDs play an essential role in treating joint and tendon injuries. However, it would help if you appreciated that NSAIDs have side effects and carry a certain level of risk. Speak to your doctor about the most appropriate NSAID for you.
Related topics:
- Amitriptyline for nerve and chronic pain
- How long does it take for a cortisone shot to work? FAQ about cortisone
Dr. Masci is a specialist sport doctor in London.
He specialises in muscle, tendon and joint injuries.
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2 Comments
Sue August 26, 2021 at 6:57 am - Reply
Hi
Just wondering g if Ibuprofen is good for long term arthritic hip pain or if it puts too much strain on the liver or other organs?Hi Sue, Thank you for your question. As a general rule, I think intermittent or occasional ibuprofen is fine for younger patients without other medical problems. However, as I outline in my blog, you need ot be careful of ibuprofen or the same class of drug if you have significant heart disease (like a previous heart attack), high blood pressure, or diabetes. If you have these conditions, you need to consider other medications such as paracetamol.
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